Production process
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The wet-granulation production process for tablets and capsules — granulation, drying, milling and blending through compression, film coating, capsule filling and bin washing (illustrative, redrawn from the line process chart).
Wet granulation
1IBC bin — charging
2High-shear mixer — wet mixing
3Fluid-bed granulator / dryer — drying
4Transfer tray
5Lifter + mill — milling
6Lifter — transfer
7IBC bin — granule hold
Tablet lines 1 & 2 (film-coated)
1IBC blender — blending / lubrication
2Drum or IBC bin — hold
3Telescopic lifter or bin lifter — transfer
4Lifter — feed to press
5Tablet compression
6Movable lifter — tablet transfer
7Film coater — coating
Capsule lines 1 & 2
1IBC blender — blending
2Drum or IBC bin — hold
3Lifter — transfer
4Capsule filling machine
Bin washing
1Automatic bin washing station
2Movable washer
Main steps
1. Wet granulation
Powders and binder are mixed in a high-shear mixer, then dried in a fluid-bed to uniform granules.
2. Milling and blending
Granules are milled to size, then blended and lubricated in an IBC blender.
3. Compression and coating
Rotary presses form tablets, followed by film coating — two tablet lines.
4. Capsule filling
Blended granules go to the capsule filling machines — two capsule lines.
5. Contained transfer
IBC bins, drums and lifters move powders and granules between machines.
6. Bin washing
Used bins go to an automatic washing station or a movable washer before reuse.
